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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 1
1953 1
1958 1
1959 2
1961 2
1964 2
1965 2
1966 7
1967 5
1968 4
1969 14
1970 7
1971 4
1972 10
1973 6
1974 6
1975 68
1976 60
1977 44
1978 42
1979 41
1980 58
1981 50
1982 74
1983 95
1984 102
1985 99
1986 99
1987 101
1988 85
1989 97
1990 119
1991 107
1992 126
1993 136
1994 136
1995 145
1996 159
1997 165
1998 172
1999 157
2000 144
2001 123
2002 135
2003 138
2004 154
2005 160
2006 145
2007 136
2008 162
2009 126
2010 127
2011 157
2012 145
2013 158
2014 147
2015 133
2016 117
2017 124
2018 108
2019 122
2020 104
2021 121
2022 88
2023 81
2024 36

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5,454 results

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Page 1
Conservation of metabolic regulation by phosphorylation and non-covalent small-molecule interactions.
Gruber CH, Diether M, Sauer U. Gruber CH, et al. Cell Syst. 2021 Jun 16;12(6):538-546. doi: 10.1016/j.cels.2021.04.009. Epub 2021 May 17. Cell Syst. 2021. PMID: 34004157 Free article. Review.
Here, we review extant observations of protein phosphorylation and small-molecule interactions in metabolism and ask which of their specific regulatory functions are conserved in Escherichia coli and Homo sapiens. ...Post-translational regulation through phosphorylation …
Here, we review extant observations of protein phosphorylation and small-molecule interactions in metabolism and ask which of their s …
Phosphorylation of Phenylalanine Hydroxylase Increases the Rate Constant for Formation of the Activated Conformation of the Enzyme.
Khan CA, Fitzpatrick PF. Khan CA, et al. Biochemistry. 2018 Nov 6;57(44):6274-6277. doi: 10.1021/acs.biochem.8b00919. Epub 2018 Oct 24. Biochemistry. 2018. PMID: 30346142 Free PMC article.
Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that is activated by phenylalanine. The enzyme is also phosphorylated by protein kinase A, but the effects of phosphorylation are unclear. ...Phosphorylation increases L 10-fold by increasing the …
Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that is activated by phenylalanine. The enzyme is also phosphorylated …
Phase plane dynamics of ERK phosphorylation.
Shvartsman SY, McFann S, Wühr M, Rubinstein BY. Shvartsman SY, et al. J Biol Chem. 2023 Nov;299(11):105234. doi: 10.1016/j.jbc.2023.105234. Epub 2023 Sep 9. J Biol Chem. 2023. PMID: 37690685 Free PMC article.
The estimation of individual reaction rate constants from kinetic data in the full mechanism has proved challenging. Here, we present an analytically tractable approach to parameter estimation that is based on the phase plane representation of ERK activation and yields two …
The estimation of individual reaction rate constants from kinetic data in the full mechanism has proved challenging. Here, we present …
Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?
Adams JA. Adams JA. Biochemistry. 2003 Jan 28;42(3):601-7. doi: 10.1021/bi020617o. Biochemistry. 2003. PMID: 12534271 Review.
We review the results of solution studies on six protein kinases that test the role of the activation loop in controlling active-site access. While loop phosphorylation enhances substrate binding in two cases, four protein kinases display little or no effect on substrate d …
We review the results of solution studies on six protein kinases that test the role of the activation loop in controlling active-site access …
Phosphorylation increases the catalytic activity of rainbow trout gill cytosolic carbonic anhydrase.
Carrie D, Gilmour KM. Carrie D, et al. J Comp Physiol B. 2016 Jan;186(1):111-22. doi: 10.1007/s00360-015-0942-4. J Comp Physiol B. 2016. PMID: 26498599
In addition, phosphorylation of tCAc by kinase stimulation significantly increased the inhibition constant (K i) for acetazolamide. These results demonstrate that tCAc is subject to reversible phosphorylation; future work should focus on identifying the physi …
In addition, phosphorylation of tCAc by kinase stimulation significantly increased the inhibition constant (K i) for acetazola …
Critical roles of IkappaBalpha and RelA phosphorylation in transitional oscillation in NF-kappaB signaling module.
Hatanaka N, Seki T, Inoue JI, Tero A, Suzuki T. Hatanaka N, et al. J Theor Biol. 2019 Feb 7;462:479-489. doi: 10.1016/j.jtbi.2018.11.023. Epub 2018 Nov 27. J Theor Biol. 2019. PMID: 30496749 Free article.
The transcription of the NF-kappaB target genes is regulated by the phosphorylation of both IkappaBalpha and the RelA subunit of NF-kappaB, suggesting that these phosphorylation events are crucial for the oscillation. ...Because the NF-kappaB oscillation is caused b …
The transcription of the NF-kappaB target genes is regulated by the phosphorylation of both IkappaBalpha and the RelA subunit of NF-k …
Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations.
Yeung E, McFann S, Marsh L, Dufresne E, Filippi S, Harrington HA, Shvartsman SY, Wühr M. Yeung E, et al. Curr Biol. 2020 Mar 9;30(5):877-882.e6. doi: 10.1016/j.cub.2019.12.052. Epub 2020 Feb 13. Curr Biol. 2020. PMID: 32059766 Free PMC article.
Multisite protein phosphorylation plays a critical role in cell regulation [1-3]. It is widely appreciated that the functional capabilities of multisite phosphorylation depend on the order and kinetics of phosphorylation steps, but kinetic aspects of multisit …
Multisite protein phosphorylation plays a critical role in cell regulation [1-3]. It is widely appreciated that the functional capabi …
Phosphorylation variation during the cell cycle scales with structural propensities of proteins.
Tyanova S, Cox J, Olsen J, Mann M, Frishman D. Tyanova S, et al. PLoS Comput Biol. 2013;9(1):e1002842. doi: 10.1371/journal.pcbi.1002842. Epub 2013 Jan 10. PLoS Comput Biol. 2013. PMID: 23326221 Free PMC article.
We find two distinct phosphorylation site groups: intrinsically disordered regions tend to contain sites with dynamically varying levels, whereas regions with predominantly regular secondary structures retain more constant phosphorylation levels. ...They also …
We find two distinct phosphorylation site groups: intrinsically disordered regions tend to contain sites with dynamically varying lev …
Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth.
Sakurai H, Ishihama A. Sakurai H, et al. Genes Cells. 2002 Mar;7(3):273-84. doi: 10.1046/j.1365-2443.2002.00522.x. Genes Cells. 2002. PMID: 11918671 Free article.
However, phosphorylated Ser2 and Ser5 were identified only in the IIo form, indicating that Ser phosphorylation contributes to the conformational change in CTD. ...CONCLUSION: The intracellular level of RNA polymerase II stays constant, but the amount engaged …
However, phosphorylated Ser2 and Ser5 were identified only in the IIo form, indicating that Ser phosphorylation contributes to …
Highly specific prediction of phosphorylation sites in proteins.
Koenig M, Grabe N. Koenig M, et al. Bioinformatics. 2004 Dec 12;20(18):3620-7. doi: 10.1093/bioinformatics/bth455. Epub 2004 Aug 5. Bioinformatics. 2004. PMID: 15297298
SUMMARY: The prediction of significant short functional protein sequences has inherent problems. In predicting phosphorylation sites, problems came from the shortness of phosphorylation sites, the difficulties in maintaining many different predefined models of bindi …
SUMMARY: The prediction of significant short functional protein sequences has inherent problems. In predicting phosphorylation sites, …
5,454 results